Table 2. Comparison of HDX Data and Homology Models.

						HDX agreement on the modelsd
regiona	categoryb	model Ac	model B	model C	model D	A	B	C	D
1–29	III	h/l	h/l	h/l	h/l	**	**	**	**
33–37	III	h/l	l	l	l	**			*
38–44	IV	h bundle	h/l	h/l	h/l				*
45–49	I	h	h bundle	h/l	h bundle		**		**
50–57	IV	l	l	h bundle	h/l				*
58–65	II	l	l	l	l	**	**	**	**
78–91	III	h/l	h/l	h/l	h/l	**	**	**	**
92–108	III	h/l	h/l	h/l	h/l	**	**	**	**
109–127	III	l	l	h/l	h/l			**	**
128–142	IV	h/l	l	l	l	*			*
143–149	I	h bundle	h bundle	h	h bundle	**	**	*	**
150–168	III	h/l	h/l	h/l	h/l	**	**	**	**
169–172	I	h	h bundle	h bundle	h bundle		**	**	**
173–208	II	h/l	l	h/l	h/l	**	**	**	**

^aRegions determined by HDX. Most of the regions are covered by multiple peptides, and they give similar results.

^bDifferent regions are assigned to four categories on the basis of their HDX behavior.

^cSecondary and tertiary structure elements in each model. h stands for helix, l for loop, h/l for a mixture of helix and loop, and h bundle for a helix bundle.

^dMeasures of degrees of agreement between HDX and modeling results. Two asterisks denote agreement. One asterisk denotes agreement with restrictions (information from order prediction by Phyre2). Blank cells denote a lack of agreement.