Table 3. Allele distributions of the single nucleotide polymorphisms of the chitinase 3-like 1 gene in patients with invasive cancer and pre-cancerous lesions of the uterine cervix and normal controls.
| Variables | Normal controls (n = 310) | Pre-cancerous lesions (n = 61) | Invasive cancer(n = 99) | P (power)a | OR (95% CI)b | OR (95% CI)c |
| rs6691378 | ||||||
| Gd | 450 | 75 | 126 | 0.008a | 1.00 | 1.00 |
| A | 170 | 47 | 72 | (0.8) | 1.66 (1.11–2.49) | 1.51 (1.08–2.12) |
| rs10399805 | ||||||
| Gd | 462 | 81 | 128 | 0.012a | 1.00 | 1.00 |
| A | 158 | 41 | 70 | (0.8) | 1.48 (0.98–2.25) | 1.60 (1.14–2.25) |
| rs4950928 | ||||||
| Cd | 508 | 103 | 174 | 0.140 | 1.00 | 1.00 |
| G | 112 | 19 | 24 | 0.84 (0.49–1.42) | 0.63 (0.39–1.00) | |
| rs880633 | ||||||
| Td | 410 | 91 | 128 | 0.144 | 1.00 | 1.00 |
| C | 210 | 31 | 70 | 0.66 (0.43–1.03) | 1.07 (0.76–1.49) |
Statistical analysis: Chi-square test.
a
p<0.05; the sample size was estimated with power (1-β), 0. 80 and α, 0.05 and the powers were calculated when the comparisons among the subgroups reached statistical significances (p<0.05) with an adequate sample size using WinPepi software, version 10.0.
b
Comparison between patients with pre-cancerous lesions and normal controls.
c
Comparison between patients with cervical cancer and normal controls.
d
Used as a reference to evaluate the odds ratio.
Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.