Table 2. Associations between the TP53 rs1042522 Arg72Pro and MDM4 rs4245739 A>C genetic polymorphisms and Non-Hodgkin Lymphoma risk.
| Genotype | Cases (n = 200) | Controls (n = 400) | ORa (95% CI) | P |
| No. (%) | No. (%) | |||
| TP53 rs1042522 Arg72Pro | ||||
| Arg/Arg | 52(26.0) | 157(39.3) | 1.00 (Reference) | |
| Arg/Pro | 103(51.5) | 180(45.0) | 1.73(1.16–2.57) | 0.007 |
| Pro/Pro | 45(22.5) | 63(15.7) | 2.18(1.32–3.59) | 0.002 |
| Pro allele frequency | 0.483 | 0.383 | ||
| MDM4 rs4245739 A>C | ||||
| AA | 187(93.5) | 346(86.5) | 1.00 (Reference) | |
| AC | 13(6.5) | 53(13.2) | 0.45(0.24–0.85) | 0.014 |
| CC | 0(0) | 1(0.3) | NC | NC |
| C allele frequency | 0.033 | 0.069 | ||
Note: NHL: Non-Hodgkin Lymphoma, OR: odds ratio, 95%CI: 95% confidence interval, NC: not calculated.
a
Data were calculated by logistic regression, adjusted for sex and age.