Table 3. Association between TP53 rs1042522 Arg72Pro variant and NHL risk stratified by selected variables.
Variable | TP53 Arg72Pro | P interaction c | |||
Arg/Arga | Arg/Pro+ Pro/Proa | ORb (95% CI) | P | ||
Age (year) | 0.122 | ||||
≤50 | 26/89 | 77/107 | 2.46(1.45–4.16) | 0.001 | |
>50 | 26/68 | 71/136 | 1.36(0.80–2.32) | 0.263 | |
Sex | 0.530 | ||||
Male | 35/101 | 93/159 | 1.72(1.08–2.73) | 0.023 | |
Female | 17/56 | 55/84 | 2.16(1.13–4.10) | 0.019 | |
Pathology | NC | ||||
T-cell | 16/157 | 34/243 | 2.50(0.78–2.90) | 0.226 | |
B-cell | 36/157 | 114/243 | 2.02(1.31–3.10) | 0.001 |
Note: NHL: Non-Hodgkin Lymphoma, OR: odds ratio, 95%CI: 95% confidence interval, NC: not calculated.
Number of case patients with genotype/number of control subjects with genotype.
Data were calculated by logistic regression, adjusted for sex and age, where it was appropriate.
P values for gene-environment interaction were calculated using the multiplicative interaction term in SPSS software.