Table 3.
Nerve conduction studies
| Nerves | Rosuvastatin (n=17)
|
P-value | Placebo (n=17)
|
P-value | ||
|---|---|---|---|---|---|---|
| Baseline | Final | Baseline | Final | |||
| Leg | ||||||
| Amplitude (μV) | 14.0±9.7 | 15.6±5.8 | 0.1 | 19.8±8.8 | 19.4±13.3 | 0.9 |
| Latency (msec) | 2.9±0.6 | 3.0±0.5 | 0.6 | 3.1±0.4 | 3.3±0.7 | 0.7 |
| Peroneal | ||||||
| Ankle width (mV) | 4.1±2.2 | 3.8±2.1 | 0.9 | 3.3±2.1 | 3.5±2.3 | 0.8 |
| Amplitude at fibula (mV) | 3.2±1.9 | 4.1±2.4 | 0.8 | 3.6±2.3 | 4.0±2.0 | 0.2 |
| Conduction velocity (m/sec) | 40.8±2.2 | 42.1±1.6 | 0.03 | 41.2±4.4 | 41.9±4.5 | 0.5 |
| Tibial | ||||||
| Amplitude ankle (mV) | 5.3±3.3 | 6.9±5.3 | 0.4 | 7.5±5.1 | 8.5±4.6 | 0.7 |
| Amplitude in popliteal fossa (mV) | 3.4±2.4 | 4.8±4.4 | 0.08 | 5.7±4.8 | 6.4±3.9 | 0.2 |
| Conduction velocity (m/sec) | 41.8±5.7 | 43.1±5.9 | 0.5 | 40.4±4.2 | 41.0±4.6 | 0.2 |
| F-wave latency (msec) | 48.2±6.5 | 49.0±7.7 | 0.5 | 47.8±4.9 | 47.6±5.4 | 0.9 |
| Arm | ||||||
| Median | ||||||
| Amplitude on wrist (μV) | 23.6±9.2 | 24.5±8.5 | 0.5 | 25.5±17.3 | 30.5±17.7 | 0.3 |
| Elbow breadth (μV) | 14.4±7.2 | 12.5±6.4 | 0.4 | 16.2±9.1 | 16.4±10.7 | 0.8 |
| Conduction velocity (m/sec) | 49.3±5.2 | 50.1±4.4 | 0.08 | 51.2±4.5 | 50.4±7.5 | 0.6 |
| Ulnar | ||||||
| Amplitude on wrist (mV) | 8.1±2.7 | 8.0±2.2 | 0.8 | 8.2±2.4 | 8.7±2.6 | 0.4 |
| Amplitude below the elbow (mV) | 7.4±4.2 | 6.6±2.2 | 0.7 | 6.9±2.5 | 7.1±2.7 | 0.7 |
| Amplitude above the elbow (mV) | 7.2±5.3 | 6.6±1.9 | 0.5 | 6.7±2.0 | 7.0±2.4 | 0.6 |
| Amplitude of armpit (mV) | 7.8±1.6 | 7.0±3.3 | 0.1 | 7.3±4.1 | 6.8±3.0 | 0.7 |
| Supraclavicular amplitude (mV) | 6.5±2.5 | 5.7±2.0 | 0.5 | 5.9±2.6 | 6.3±1.7 | 0.5 |
| Velocity below the wrist (m/sec) | 48.9±6.2 | 51.2±6.2 | 0.3 | 49.5±6.5 | 50.0±6.6 | 0.9 |
| Velocity below and above the elbow (m/sec) | 50.6±8.5 | 48.9±11.6 | 0.3 | 50.4±6.1 | 50.0±9.2 | 0.2 |
| Velocity above the elbow-armpit (m/sec) | 50.4±2.7 | 51.6±7.0 | 0.5 | 50.8±6.5 | 51.9±6.1 | 0.5 |
| Supraclavicular velocity axillary fossa (m/sec) | 54.5±9.1 | 53.6±5.7 | 0.5 | 52.1±8.9 | 51.7±4.7 | 0.4 |
| F-wave latency (msec) | 26.5±1.7 | 26.3±2.1 | 0.9 | 26.9±3.2 | 27.0±3.5 | 0.7 |
Notes: There was a significant increase in conduction velocity of the peroneal nerve in the rosuvastatin group and a tendency towards significance in amplitude of the tibial nerve in the popliteal fossa and conduction velocity of the median nerve (P<0.08). There was no significant difference between baseline and final nerve conduction studies in the control group. The bold P-value indicates statistical significance.