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. 2014 Sep 9;9(9):e107135. doi: 10.1371/journal.pone.0107135

Figure 4. NOX4 knockdown inhibits proliferation of PASMCs under both control and BMP4 treatment circumstances A: control group was the control group absorbance at 490 nm, BMP4 group was absorbance of recombinant BMP4 protein intervention for 24 h group at 490 nm, #indicates P<0.01 vs. control group, the results are statistically significant.

Figure 4

B: absorbance of rat distal PASMCS at 490 nm after transfection with NOX4 siRNA and knockout of NOX4, NC indicates negative control group; NOX4 siRNA indicates NOX4 gene silencing group; #indicates P<0.01 vs. negative control group, results have statistically significance. C: absorbance of rat distal PASMCS at 490 nm after transfection with NOX4 siRNA and knockout of NOX4, and treatment with recombinant BMP4 for 24 hours. NC+BMP4 group indicates negative control+BMP4 treatment group; NOX4 siRNA+BMP4 group was BMP4 with silent NOX4 group, #indicates P<0.01 vs. negative control+ BMP4 group, the results are statistically significant.