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. 2014 Sep 9;9(9):e107369. doi: 10.1371/journal.pone.0107369

Figure 5. ER-α36 disruptor Broussoflavonol B restores TAM sensitivity.

Figure 5

A. Western blot analysis of the expression of ER-α36, ER-α66, EGFR and HER2, and levels of EGFR and HER2 phosphorylation in parental MCF7 (MCF7/P) and MCF7/TAM cells treated with indicated concentrations of Broussoflavonol B (BB) for 12 hours. B. Cells were treated with indicated concentrations of tamoxifen (TAM) together with vehicle or 1 µM of Broussoflavonol B (BB) for seven days and the numbers of survived cells were counted. The columns represent the means of three experiments; bars, SE. *, P<0.05 for MCF/TAM cells treated with vehicle vs cells treated with 1 µM of tamoxifen and BB.