. 2014 Sep 9;9(9):e107368. doi: 10.1371/journal.pone.0107368

Table 1. Morphological measurements of the brains of radiation-exposed and control rats using MRI.

Radiation dose	Control	0.5 Gy	1.0 Gy	1.5 Gy
Brain volume (mm³)	1756±78.9	1321.9±72.4^***	1062.2±109.8^***	828.2±42.8^***
Ventricle volume (mm³)	1.7±0.5	3.4±1.0	6.4±1.4^***	27.1±3.3 ^***
Cortex thickness (µm)	1662.5±89.8	1452.5±143.6^**	963.0±120.9^***	829.3±136.2^***
CC thickness (µm)	627.2±118.0	536.8±89.3	477.7±61.3^**	N.D. (Split)
EC thickness (µm)	545.3±76.2	501.7±63.9	315.6±35.2^***	257.3±35.6^***

The brain size of 4-week-old radiation-exposed rats was smaller than that of the 4-week-old control rats. In contrast, the volume of the lateral-plus-3rd ventricles of 4-week-old rats exposed to 1.0 or 1.5 Gy of radiation was larger than that of the control rats. The thicknesses of the cortex, CC, and EC of 4-week-old rats exposed to 1.0 or 1.5 Gy of radiation were less than those of the control rats. Significant thinning of the cortex was also found for the smallest dose, vs. control, P<0.05;

**, vs. control, P<0.01;

***, vs. control, P<0.001