. 2014 Sep 9;9(9):e107392. doi: 10.1371/journal.pone.0107392

Table 1. Gene expression for cecal SCFA transport, hepatic gluconeogenesis and glycolysis and hepatic fatty acid synthesis and oxidation for the different guar gum groups.

	Control	Guar Gum 5%	Guar Gum 7.5%	Guar Gum 10%
SCFA transport
Mct-1	1.00±0.13^a	1.62±0.06^b	1.32±0.13^a	1.23±0.06^a
Smct-1	1.00±0.09^a	4.55±0.48^b	4.14±0.31^b	3.08±0.13^c
Gluconeogenesis
Pepck	1.00±0.11^a	0.90±0.11^a	0.64±0.05^b	0.50±0.08^c
G6Pase	1.00±0.14^a	0.70±0.10^b	0.47±0.11^c	0.33±0.03^c
PC	1.00±0.11^a	0.87±0.04^a	0.79±0.07^b	0.74±0.06^b
Glycolysis
HK	1.00±0.07^a	1.50±0.19^a	2.08±0.33^b	3.02±0.53^c
PK	1.00±0.10^a	1.10±0.12^a	1.45±0.14^b	1.69±0.19^b
Fatty acid synthesis
Fasn	1.00±0.04^a	0.71±0.06^b	0.69±0.08^b	0.51±0.05^c
Acc1	1.00±0.08^a	0.84±0.05^a	0.73±0.08^b	0.66±0.06^b
Acc2	1.00±0.09^a	0.88±0.10^a	0.83±0.08^b	0.56±0.05^b
Elovl6	1.00±0.14^a	0.86±0.07^a	0.75±0.07^b	0.67±0.08^b
Fatty acid oxidation
Cpt-1a	1.00±0.07^a	0.88±0.11^a	0.84±0.06^a	0.84±0.07^a
Mcad	1.00±0.06^a	1.10±0.12^a	1.01±0.09^a	1.01±0.10^a
Lcad	1.00±0.04^a	0.94±0.08^a	0.96±0.07^a	0.94±0.07^a
Aox	1.00±0.04^a	1.03±0.04^a	1.12±0.07^a	0.96±0.06^a

Mct-1, Monocarboxylate transporter 1; Smct-1, sodium-coupled monocarboxylate transporter 1; Pepck, phosphoenolpyruvate carboxykinase; G6Pase, glucose 6-phosphatase; PC, pyruvate carboxylase; HK, hexokinase; PK, pyruvate kinase; Fasn, fatty acid synthase; Acc1, acetyl-CoA carboxylase 1; Acc2, acetyl-CoA carboxylase 2; Elovl6, fatty acid elongase 6; Cpt-1a, carnitine palmitoyltransferase 1a; Mcad, medium-chain acyl coA dehydrogenase; Lcad, long-chain acyl coA dehydrogenase; Aox, acyl-CoA oxidase.

Data represent means ± SEM for n = 7–8. When groups have a different superscript a, b or c associated, the results differ significantly between them (at least p<0.05).