Table 1.
Strength of MPI signal in blood, measured by MPS as the percentage of the highest blood MPI signal directly after administration of Resovist® at baseline
| Baseline | 5 minutes | 10 minutes | 15 minutes | 30 minutes | |
|---|---|---|---|---|---|
| Resovist (Bayer Pharma AG) | 100% | 39.7%±8% | 20.5%±6% | 12.1%±5% | 31%±3%a |
| Resovist (I’rom Pharmaceutical Co Ltd) | 100% | 20.4%±10% | 7.8%±4% | 1.9%±2%a | 0.7%±0.4%a |
| Mean | 100% | 30.0%±13% | 14.8%±7.8% | 7.0%±6% | 1.9%±2%a |
Notes: Values are shown as the mean ± standard deviation. There is a statistically significant difference in signal decay between of the two types of Resovist (P=0.0056, Mann–Whitney U-test). From 30 to 120 minutes, in case of Resovist (I’rom Pharmaceutical Co Ltd) after 15 minutes, there was no measurable signal above the noise level of the magnetic particle spectrometer.
a
Signal below noise level.
Abbreviations: MPI, magnetic particle imaging; MPS, magnetic particle spectroscopy.