Table 2.
Mean Proton Density Fat Fraction, % (SD) and Cumulative Mean Dose, Gy (SD) by MRI Study Visit, Treatment Group and Vertebral Column Region
| Baseline | Mid-Treatment | Post-Treatment | |||||
|---|---|---|---|---|---|---|---|
| Treatment Group | Region | PDFF(%) | Cum. Dose | PDFF(%) | Cum. Dose | PDFF(%) | Cum. Dose |
| Highly Myelotoxic | C3-T9 | 33.0 (11.1) | 0 | 34.9 (11.5) | 0 | 30.5 (15.5) | 0 |
| T10-L3 | 36.0 (13.9) | 0 | 41.2 (14.1) | 0.42 (0.78) | 42.0 (18.7) | 0.60 (1.07) | |
| L4-S2 | 43.2 (16.5) | 0 | 64.3 (15.5) | 19.3 (5.85) | 74.1 (15.5) | 28.3 (5.37) | |
| All Vertebrae (C3-S2) | 37.5 (14.4) | 0 | 46.5 (18.3) | 6.77 (9.79) | 49.7 (23.7) | 9.93 (13.9) | |
| Less Myelotoxic | C3-T9 | 47.2 (11.5) | 0 | 48.0 (11.0) | 0 | 41.4 (11.3) | 0 |
| T10-L3 | 52.6 (12.8) | 0 | 51.8 (13.4) | 0.17 (0.11) | 47.9 (11.7) | 0.28 (0.09) | |
| L4-S2 | 61.6 (11.2) | 0 | 70.3 (14.2) | 18.9 (7.68) | 77.8 (12.7) | 28.0 (3.86) | |
| All Vertebrae (C3-S2) | 53.6 (13.1) | 0 | 57.1 (15.3) | 6.67 (10.2) | 55.8 (18.9) | 9.41 (13.7) | |
Abbreviations: SD = standard deviation; C = cervical vertebrae; T = thoracic vertebrae; L = lumbar vertebrae; S = sacral vertebrae; PDFF(%) = proton density fat fraction; Cum. Dose = cumulative mean dose (in Gy)