Table 5.

Hazard ratios (HRs) and 95% confidence intervals (CIs) of colorectal cancer, overall and by subsite, according to intake of marine ω-3 polyunsaturated fatty acids with variable latency periods in the Health Professionals Follow-up Study¹

	No. of cases	HR (95% CI)				P for trend
		<0.16 g/d	≥0.16 to <0.27 g/d	≥0.27 to <0.41 g/d	≥0.41 g/d
Colorectal cancer
0-4-year lag	847	1.00 (referent)	1.03 (0.84-1.26)	1.21 (1.00-1.46)	1.06 (0.87-1.30)	0.53
4-8-year lag	569	1.00 (referent)	1.05 (0.81-1.35)	1.09 (0.87-1.37)	0.92 (0.71-1.18)	0.46
8-12-year lag	363	1.00 (referent)	1.05 (0.78-1.41)	0.96 (0.71-1.28)	0.90 (0.66-1.24)	0.48
12-16-year lag	253	1.00 (referent)	0.85 (0.60-1.20)	0.86 (0.61-1.20)	0.76 (0.52-1.10)	0.15
Proximal colon cancer
0-4-year lag	307	1.00 (referent)	0.86 (0.60-1.21)	1.20 (0.88-1.63)	1.12 (0.80-1.56)	0.38
4-8-year lag	200	1.00 (referent)	0.81 (0.52-1.25)	0.89 (0.61-1.31)	0.81 (0.54-1.23)	0.39
8-12-year lag	133	1.00 (referent)	0.78 (0.48-1.28)	0.62 (0.37-1.02)	0.72 (0.43-1.20)	0.17
12-16-year lag	94	1.00 (referent)	1.00 (0.57-1.75)	0.86 (0.49-1.51)	0.69 (0.35-1.33)	0.25
Distal colon cancer
0-4-year lag	263	1.00 (referent)	1.24 (0.87-1.76)	1.30 (0.93-1.82)	1.02 (0.70-1.49)	0.96
4-8-year lag	187	1.00 (referent)	1.21 (0.78-1.89)	1.61 (1.09-2.39)	0.79 (0.49-1.28)	0.34
8-12-year lag	113	1.00 (referent)	1.94 (1.13-3.33)	1.80 (1.06-3.06)	1.35 (0.73-2.48)	0.43
12-16-year lag	72	1.00 (referent)	0.68 (0.33-1.40)	1.07 (0.58-1.94)	0.80 (0.39-1.65)	0.71
Rectal cancer
0-4-year lag	186	1.00 (referent)	0.98 (0.63-1.52)	1.17 (0.78-1.75)	1.04 (0.68-1.59)	0.82
4-8-year lag	121	1.00 (referent)	1.18 (0.69-2.01)	0.96 (0.58-1.61)	0.99 (0.58-1.69)	0.87
8-12-year lag	85	1.00 (referent)	0.91 (0.49-1.68)	0.90 (0.50-1.62)	0.69 (0.35-1.35)	0.28
12-16-year lag	65	1.00 (referent)	1.06 (0.54-2.06)	0.79 (0.39-1.61)	0.68 (0.33-1.43)	0.27

¹Cox proportional hazards models were used and adjusted for the same sets of covariates as in Table 3.