. 2014 Mar 17;16(9):801–806. doi: 10.1111/hpb.12226

Table 4.

Comparison of risk factors for GC in the literature

GC study			Risk factors (P-value for predicting GC)
First Author, year^ref	No. (%) with GC	Total no. with AC	Age (years)	Gender	DM	HR
Fagan, 2003¹²	40%	113	>51 (0.04)^a	NS	Yes (0.045)^b	NS
Nguyen, 2004¹¹	18%	98	NS	NS	Yes (<0.1)^b	NS
Aydin, 2006²	10%	203	59 versus 51^c (0.001)^a	Male (0.005)^b	Yes (0.005)^b	NS
Yacoub, 2010¹⁰	28%	245	>45 (0.019)^b	Male (0.001)^b	NS	>90 (0.007)^b
Nikfarjam, 2011³	37%	290	69 versus 57 (0.001)^a	Male (0.001)^a	Yes (0.04)^a	>100 (0.001)^a
Falor, 2012¹³	23%	391	46 versus 39 (0.007)^a	Male (0.001)^b	NS	>90 (0.02)^b
Current study, 2013	6.7%	5243	>45 (0.001), >65 (0.001)^b	Male (0.001)^a	NS	>90 (0.02)^b
Risk factors (P-value for predicting GC)						Scoring system
WBC (×1000)	ALT	AP	Na	GBWT (mm)	PCCF	Scoring system
>15 (0.001)^b	>50 (0.035)^b	>200 (0.026)^b	NS	NS	Yes (0.11)^b	No
>15 (<0.1)^b	>50 (<0.1)^b	>200 (<0.1)^b	NS	NS	Yes (<0.1)^b	No
>15 (0.001)^b	56 versus 43 (0.02)^a	268 versus 222 (0.02)^a	NS	6.2 versus 4.6 (0.0001)^a	Yes (0.0001)^a	No
>13 (0.005)^b	NS	NS	NS	>4.5 (0.014)^b	NS	Yes
13 versus 11 (0.001)^a	26 versus 43 (0.001)^a	NS	NS	ND (0.03)^a	NS	No
>14 (0.001)^b	NS	NS	≤135 (0.04)^b	NS	NS	No
>13 (0.001)^b	NS	NS	NS	>4.5 (0.007)^b	Yes (0.001)^a	Yes

In univariate analysis only

Confirmed in multivariate analaysis

X versus Y signifies GC versus non-GC.

ALT, alanine aminotransferase; AP, alkaline phosphatase; DM, diabetes mellitus; GBWT, gallbladder wall thickening; HR, heart rate; ND, not defined; NS, not significant or not shown; PCCF, pericholecystic fluid; WBC, white blood cell count.