Table 3.

Demographic, clinical and pathological factors in patients with and without perineural invasion

Demographic, clinical and pathological factors	Patients with perineural invasion (n = 13), n	Patients without perineural invasion (n = 246), n	P-value
Demographic factors
Age ≥65 years	6	171	0.078
Male gender	9	157	0.692
Synchronous presentation	3	102	0.188
Extent of surgery
Hemi-hepatectomy or more	10	113	0.029
Pathological factors
Largest tumour size ≥5 cm	7	79	0.105
Solitary hepatic metastases	4	123	0.172
Lymphatic invasion	7	35	<0.001
Vascular invasion	11	104	0.003
Biliary invasion	11	83	<0.001
Resection margin	12	193	0.231