Fig. 7.

Impact of wheel running in the expression of skeletal muscle angiogenic and metabolic genes. a Vascular endothelial growth factor A (Vegfa), b peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α), c deacetylase sirt1, d insulin-sensitive glucose transporter type 4 (Glut4), and e fatty acid translocase Cd36. Analysis was performed by quantitative real-time PCR from gastrocnemius muscle mRNA. Gene expression levels are expressed relative to housekeeping TATA-binding protein (TBP) gene. fCON sedentary-control female mice, fWR wheel-runner female mice (mean ± SEM; *p < .05; **p < .01; ***p < .001; n = 5 per group)