Table 1.
Controls (n = 10) | Wilcoxon | Peritonitis (n = 10) | Wilcoxon | Welch rank | |||
---|---|---|---|---|---|---|---|
Baseline | 27 hours | ( P value) | Baseline | 27 hours | ( P value) | ( P value) | |
Weight (kg) | 39.1 ± 3.7 | 40.2 ± 2.3 | |||||
Core temperature (°C) | 38.50 ± 0.65 | 40.59 ± 0.34 | 0.0039** | 38.16 ± 0.76 | 40.77 ± 0.37 | 0.002** | 0.39 |
Mean arterial pressure (mmHg) | 76.0 ± 14.3 | 88.6 ± 12.7 | 0.002** | 78.6 ± 12.5 | 66.5 ± 19.9 | 0.16 | 0.009** |
Heart rate (bpm) | 80.1 ± 16.6 | 82.9 ± 20.7 | 0.82 | 68.5 ± 12.2 | 143.9 ± 25.4 | 0.002** | 0.00009**** |
Cardiac output (l/min) | 5.0 ± 1.3 | 4.6 ± 0.6 | 0.50 | 4.5 ± 0.9 | 4.8 ± 1.2 | 0.84 | 0.92 |
Stroke volume | 63.2 ± 9.3 | 57.7 ± 10.1 | 0.65 | 65.9 ± 7.1 | 39.1 ± 13.7 | 0.004** | 0.0011** |
Sodium (mmol/l) | 135.5 ± 1.9 | 141.5 ± 2.4 | 0.004** | 134.3 ± 2.5 | 131.4 ± 2.6 | 0.19 | 0.00008**** |
Potassium (mmol/l) | 4.0 ± 0.4 | 4.1 ± 0.2 | 0.61 | 4.0 ± 0.2 | 4.1 ± 0.4 | 0.76 | 0.76 |
Glucose (mmol/l) | 8.4 ± 1.3 | 5.4 ± 0.4 | 0.002** | 9.4 ± 1.3 | 5.0 ± 1.0 | 0.002** | 0.21 |
Lactate (mmol/l) | 1.2 ± 1.1 | 1.1 ± 0.4 | 0.77 | 1.0 ± 0.6 | 1.8 ± 0.7 | 0.05* | 0.016* |
pH | 7.52 ± 0.04 | 7.47 ± 0.02 | 0.002** | 7.51 ± 0.04 | 7.41 ± 0.06 | 0.004** | 0.010* |
Bicarbonate (mmol/l) | 32.6 ± 1.8 | 31.4 ± 3.0 | 0.27 | 32.2 ± 1.5 | 26.9 ± 2.8 | 0.004** | 0.004** |
Base excess (mmol/l) | 9.1 ± 2.7 | 7.9 ± 2.8 | 0.39 | 9.3 ± 1.9 | 2.5 ± 3.6 | 0.006** | 0.006** |
TNFα (pg/ml) | 86.6 ± 76.2 | 60.9 ± 22.7 | 0.30 | 69.6 ± 46.9 | 317.6 ± 187.8 | 0.006** | 0.002** |
Wilcoxon test was used for comparison of baseline and 27-hour measurements within each group. Welch test of ranked data was used to compare 27-hour measurements between controls and animals with peritonitis. (* = P <0.05, ** = P <0.01, **** = P <0.0001). TNFα, tumour necrosis factor alpha.