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. 2014 Aug 26;14:614. doi: 10.1186/1471-2407-14-614

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© Korpela et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effect of VT on irradiation-induced acute cutaneous damage. (A) Single large 40 Gy fraction of IR and resulting skin toxicity treatment schedule and data collection outline. (B) Photographs of radiation dermatitis in PBS (top) or VT-treated (bottom) mice at baseline (day 0) and up to 28 days after irradiation. Scale bars = 1 cm. (C) Acute skin damage scores of mice exposed to IR over time expressed as group medians ± interquartile range. (D) Absolute surface area of wound moist desquamation and scabbing following irradiation expressed as group means ± SD. (E) Mean weights ± SD of PBS/VT-treated irradiated and non-irradiated animals over time. * and ** indicate P < 0.05 and P < 0.01, respectively, and “ns” denotes ‘not significant’.