Table 2.
Children with suspected primary immunodeficiency disease with results of immunological analysis outside reference intervals
| Study (n = 259) a No. (%) | Excluded (n = 41) b No. (%) | Skåne c county No. (%) | |||
|---|---|---|---|---|---|
| Immunoglobulins | IgG | 21 (8.1) | 0 | 16 (1.5) | |
| IgA | 0 | 0 | 1 (0.1) | n = 1056 | |
| IgM | 21 (8.1) | 0 | 37 (3.5) | ||
| Immunoglobulin subclasses | IgG1 | 0 | 0 | 10 (1.0) | n = 1080 |
| IgG2 | 24 (9.2) | 0 | 59 (5.4) | ||
| IgG3 | 4 (1.4) | 0 | 0 | ||
| IgG1 + IgG2 | 1 (0.4) | 0 | 3 (0.3) | ||
| IgG1 + IgG3 | 0 | 0 | 3 (0.3) | ||
| IgG2 + IgG3 | 1 (0.4) | 0 | 1 (0.1) | ||
| Lymphocytes | T cells | 34 (13.1) | 5 (12.2) | 17 (4.8) | n = 348 |
| T helper cells | 2 (0.7) | 0 | 1 (0.3) | ||
| T cytotoxic cells | 4 (1.4) | 2 (4.8) | 0 | ||
| B cells | 19 (7.3) | 1 (2.4) | 4 (1.1) | ||
| NK cells | 13 (5.0) | 0 | 13 (3.7) | ||
| Complement | Classical pathway | 9 (3.5) | 1 (2.4) | 26 (1.7) | n = 1473 |
| Alternative pathway | 5 (1.9) | 0 | 14 (0.9) | ||
| Lectin pathway | 63 (24.3) | 4 (9.6) | 26 (18.4) | n = 141 | |
aPatients fulfilling the study inclusion criteria.
bThe 41 patients not fulfilling the study inclusion criteria but with results from the predefined set of immunological analyses (the 27 patients excluded because of known genetic diseases are omitted).
cOther patients with infections in which immunological analyses were performed.