Table 3.

Crude incident cancer rate and SIR by country for COGHD group

Country	N	Follow-up years	Crude incidence (100,000 person-years) (95 % CI)	Observed cancer cases	Expected cancer cases	SMR (95 % CI)
United Kingdom	31	127.2	786.3 (19.9–4,381.0)	1	0.119	8.37 (0.21–46.6)
Overall	1,056	3,965.4	25.2 (0.6–140.5)	1	3.718	0.27 (0.01–1.50)

Incidence rate per 100,000 person-years = observed number of incident events × 100,000/total person-years. Expected number of events = sum of person-years × incidence rate for each age-gender group. Overall expected number of events = sum of expected incident events in each country. Overall observed number of events = sum of observed incident events in each country. Data for those countries without an event are depicted. However, the total person-years of follow-up and expected number of deaths are included in the overall estimate row. SIR = observed number of events/expected number of events. 95 % CI is the exact confidence interval based on Poisson distribution. Reference data sources for calculating expected cases: http://seer.cancer.gov/statistics for US data and http://globocan.iarc.fr for non-US data

CI confidence interval, COGHD group those patients with childhood-onset GH deficiency who received GH replacement during childhood and had available information on age, gender, and at least one follow-up visit, GH growth hormone, N number of patients, SIR standardized incidence ratio