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Grading system for GEP-NENs (adapted from 19)
| Ki-67 index (%)a | Mitotic count/10 HPFb | |
|---|---|---|
| NET G1 | ≤2 | <2 |
| NET G2 | 3–20 | 2–20 |
| NEC G3 | >20 | >20 |
aAssessed by MIB-1 labeling in at least 2,000 tumor cells in high nuclear density (“hot spot”) areas
b10 HPF = 2 mm2, at least 50 optical fields in high-density mitotic areas
