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. Author manuscript; available in PMC: 2015 Sep 8.
Published in final edited form as: Cancer Cell. 2014 Sep 8;26(3):390–401. doi: 10.1016/j.ccr.2014.07.023

Figure 4. Genetic interaction of Notch activation and p53 loss of function in OS development.

Figure 4

(A) Quantitative RT-PCR analysis of genes associated with human OS comparing Notch-induced OS with normal bone (mean ± SD of three mice per group). *p<0.05 (Student's t test).

(B) Kaplan-Meier survival plots of p53cKO, p53cKO-cNICD and p53cKO-RbpjcKO mice.

(C) Summary of genetic studies from each cohort of mice. Mice without bone tumors were sacrificed by 450 days of age in cohorts of p53cKO (8 of 35), p53cKO-RbpjcKO (8 of 34), and cNICD-RbpjcKO (16 of 16). The p values were calculated using SigmaPlot through all Pairwise Multiple Comparison Procedures (Holm-Sidak method). fl, Flox; n.s, not significant.

See also Figure S4

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