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. Author manuscript; available in PMC: 2015 Sep 8.
Published in final edited form as: Cancer Cell. 2014 Sep 8;26(3):390–401. doi: 10.1016/j.ccr.2014.07.023

Figure 5. Expression signature of NOS compared to p53-loss-induced OS.

Figure 5

(A) Unsupervised hierarchical clustering of mouse samples and heat map of RNA-sequencing data between Notch OS or p53-loss-induced tumors (p53 OS)

(B) Ingenuity Pathways Analysis (IPA) of cancer canonical signaling pathways associated with significantly regulated genes (p<0.05) in Notch OS versus control. Significantly changed pathways only observed in NOS are colored in light blue, and those changed in both NOS and p53-induced OS are shown in black.

(C) GSEA results for each of the indicated human sarcomas for NOS primary malignant tumors. Asterisks indicate statistical significance. NOM p val, nominal p value; FDR, false discovery rate; FWER, family-wise error rate. See also Figure S5, Tables S1, S2, S3, and S4.

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