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. Author manuscript; available in PMC: 2015 Sep 8.
Published in final edited form as: Cancer Cell. 2014 Sep 8;26(3):390–401. doi: 10.1016/j.ccr.2014.07.023

Figure 6. Candidate cells of origin in murine OS models.

Figure 6

(A) Kaplan-Meier survival plots of p53cKO, Osxp53cKO and Prxp53cKO mice.

(B) Summary of genetic studies from each cohort of mice. The p values were calculated using SigmaPlot (Holm-Sidak method). *There is no significant difference (p=0.153) between Osxp53cKO and Prxp53cKO.

(C) Summary of results from various genetic experiments. Loss of function of p53 can induce OS at the early and late stage of MSC differentiation, but Notch gain of function can only induce OS at a late stage.

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