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A model for spatial regulation of RacGAP1 by APC/C-mediated ubiquitination. Most RacGAP1 is recruited to the midbody as a heterotetrameric complex with MKLP1, where it recruits ECT and suppresses Rac1 activity to bring about cleavage furrow ingression. Any non-midbody-associated RacGAP1 can potentially interfere with cytokinesis through inappropriate recruitment of ECT2 or suppression of Rac1 (32, 63) and is targeted for ubiquitination on K292 by the APC/C.
