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Schematic construction of the function H(N) to be minimized in order to determine the normalization coefficients for each LC-MS/MS run. Intensity distributions of three peptides (orange, green, and red) over samples and fractions are indicated by the sizes of the circles. H(N) is the sum of the squared logarithmic changes in all samples (A, B, C, …) for all peptides (P, Q, R, …). When using the fast normalization option, only a subset of all possible pairs of samples will be considered.
