Table 2.
microRNAs showing varied changes in their expression following SCI in animal models.
| Expression patterns | miRNA detected at different time points | References |
|---|---|---|
| miRNAs with early up-regulation at 4 h post-SCI followed by down-regulation at 1 day post-SCI | miR-99a, miR-100, miR-103, miR-107, miR-124, miR-127, miR-128, miR-154, miR-181a, miR-434, miR-487b, miR-124a | 16, 32, 36 |
| miRNAs with early up-regulation at 4 h post-SCI followed by down-regulation at 7 days post-SCI | miR-133a, miR-133b, miR-45 | 16, 41 |
Several miRNAs show varied changes in their expression and the varied time can be the 1 day or the 7 days after SCI.
Injury models:
15. Adult female SD rats (200-230 g) underwent a T10 contusive spinal cord injury using an NYU impactor (10 g, 12.5 mm)
76. Male C57BL/6 mice, approximately 8 weeks of age, SCI was made at the level of T11-12 by compressing the cord laterally from both sides for 10 s with a number 5 forceps (FONTAX, Lausanne, Switzerland) modified with a spacer so that a 0.5 mm space remained at maximal closure
31. Adult, female Wistar rats weighing approximately 200 g, Animals were anesthetized with intraperitoneal sodium pentobarbital at 40 mg/kg (Dolethal, Vetoquinol, Lure Cedex, France). Contusion was performed at vertebral thoracic level 8 (T8) using an IH Spinal Cord Impactor from Precision System and Instrumentation, LLC, Va, which induced an impact of 200 kilodynes
16. Adult female ICR mice weighing 30 g (6 weeks of age, The contusion injuries were delivered to the T11 spinal cord following a L1 laminectomy
14. Adult female ICR mice weighing 30 g (*6 weeks of age), remove the neural spines of the T9 and T10 thoracic vertebrae and to carry out a laminectomy to expose the outer surface of the spinal dura mater
46.Adult, female Sprague-Dawley rats (225-250 g), T10, gentle aspiration
61. Adult zebrafish (Danio rerio, body length > 2.5 cm, age > 6 months), thoracic level, complete transection
50.- Sprague Dawley rats, T10, Contusion, mod. AllenWeight Drop (8 g, 40 mm)
79.- Rats, lumbo-sacral segments, Ischemic-Reperfusion