Table 1.

Unadjusted comparison of IRAK-1 variant and normal haplotype demographics, injury characteristics and outcomes.

	IRAK-1 Variant (n=40)	Normal Haplotype (n=281)	p-value
Age (years)	47±22	50±19	0.388
Sex (%Male)	87.5%	67.3%	0.009
Race (%Caucasian)
Caucasian	72.5%	81.5%
African American	7.5%	2.5%	0.176
Other/Unknown	20%	16.0%
ED SBP (mmHg)	130±25	129±28	0.817
ED GCS	15 [14,15]	15 [14,15]	0.645
Injury Severity Score (ISS)	17 [13,20]	16 [10,21]	0.442
Intubation Status (%yes)	16.7%	11.2%	0.573
Body Mass Index (BMI)	26.9±4	29.2±7	0.078
ICU Days	6.3±7	5.2±6	0.289
Length Of Stay	12±10	11±9	0.337
24 hour Crystalloid (cc)	3770±2900	3290±2160	0.249
24 hour Blood Transfusion (cc)	447±820	437±1010	0.956
24 hour Plasma Tranfusion (cc)	179±653	218±790	0.786
24 hour Platelet Transfusion (cc)	114±326	70±227	0.328
Nosocomial Infection	33.3%	26.1%	0.381
Pneumonia	21.2%	18.3%	0.683
MOF%	18.2%	5.4%	0.006
Mortality %	12.5%	3.2%	0.007

ED SBP – emergency department systolic blood pressure; GCS- glascow coma score; ICU- intensive care unit, MOF-multiple organ failure