Table 1.
Per-allele OR and 95% CI for the association of established cancer susceptibility loci and breast cancer risk by E-cadherin tumor expression for two selected SNPs
| Locus (Gene) | SNP | MAFa | Study | Controls, N | Case-control analyses
|
Case-only
|
|||
|---|---|---|---|---|---|---|---|---|---|
| N | OR (95% CI) | N | OR (95% CI) | P-hetb | |||||
| E-cad low tumors vs. controls | E-cad high tumors vs. controls | ||||||||
| 1p11.2 (NOTCH2/FCGR1B) | rs11249433 (A/G)c | 0.369 | PBCS | 2340 | 250 | 1.30 (1.08–1.56) | 989 | 1.06 (0.95–1.18) | 0.05 |
| 0.409 | SEARCH | 6714 | 468 | 1.30 (1.14–1.49) | 1524 | 1.11 (1.03–1.21) | 0.04 | ||
| Combined | 9054 | 718 | 1.30 (1.16–1.44) | 2513 | 1.09 (1.02–1.16) | 0.004 | |||
| 6q25.1 (ESR1) | rs2046210 (G/A) | 0.294 | PBCS | 2291 | 239 | 1.43 (1.18–1.75) | 949 | 1.06 (0.94–1.19) | 0.007 |
| 0.354 | SEARCH | 6716 | 465 | 0.96 (0.83–1.10) | 1517 | 1.16 (1.07–1.26) | 0.01 | ||
| Combined | 9007 | 704 | 1.18 (0.71–1.64) | 2466 | 1.12 (1.02–1.21) | 0.84 | |||
a
Minor allele frequency over all controls in PBCS.
b
Case-only P-value was used to test for heterogeneity (Phet) and was estimated using a polytomous logistic regression model with E-cadherin (E-cad) status as the outcome adjusted for age in 5-year categories.
c
Major/minor allele. Fixed effects meta-analysis by study (PBCS and SEARCH) was used to calculate the combined OR, 95% CI and Phet.