Table 2.
Genotype distribution of the studied SNPs among the breast cancer patients by study
| ABCS (n=1442) | HABCS (n=794) | HEBCS (n=925) | PBCS (n=1540) | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| n | % | n | % | n | % | n | % | |
| PRKAG2-01(rs1029946) | ||||||||
| AA | 1112 | 78.1 | 598 | 75.7 | 715 | 77.9 | 1035 | 70.3 |
| AG | 278 | 19.5 | 178 | 22.5 | 190 | 20.7 | 393 | 26.7 |
| GG | 33 | 2.3 | 14 | 1.8 | 13 | 1.4 | 44 | 3.0 |
| missing | 19 | 4 | 7 | 68 | ||||
| PRKAG2-02(rs4726050) | ||||||||
| AA | NA | NA | 296 | 37.5 | 468 | 50.8 | 519 | 34.9 |
| AG | NA | NA | 366 | 46.4 | 373 | 40.5 | 697 | 46.8 |
| GG | NA | NA | 127 | 16.1 | 81 | 8.8 | 272 | 18.3 |
| missing | 5 | 3 | 52 | |||||
| PRKAG2-03(rs6464153) | ||||||||
| GG | 1211 | 84.7 | 664 | 83.7 | 791 | 86.3 | 1190 | 78.5 |
| GA | 204 | 14.3 | 125 | 15.8 | 122 | 13.3 | 306 | 20.2 |
| AA | 14 | 1.0 | 4 | 0.5 | 4 | 0.4 | 19 | 1.3 |
| missing | 13 | 1 | 8 | 25 | ||||
| PRKAG2-04(rs7789699) | ||||||||
| GG | 447 | 31.3 | 191 | 24.1 | 248 | 27.0 | NA | NA |
| GA | 610 | 42.8 | 408 | 51.4 | 457 | 49.7 | NA | NA |
| AA | 369 | 25.9 | 195 | 24.6 | 215 | 23.4 | NA | NA |
| missing | 16 | 0 | 5 | |||||
| PPP2R2B(rs10477313) | ||||||||
| GG | 1041 | 73.7 | 610 | 77.0 | 747 | 81.1 | 1200 | 79.6 |
| GA | 265 | 18.8 | 170 | 21.5 | 161 | 17.5 | 287 | 19.0 |
| AA | 106 | 7.5 | 12 | 1.5 | 13 | 1.4 | 21 | 1.4 |
| missing | 30 | 2 | 4 | 32 | ||||
| MDM2(rs2279744) * | ||||||||
| TT | 483 | 41.7 | 325 | 41.6 | 776 | 34.6 | 628 | 41.9 |
| TG | 517 | 44.6 | 351 | 44.9 | 1110 | 49.4 | 702 | 46.8 |
| GG | 158 | 13.6 | 105 | 13.4 | 360 | 16.0 | 170 | 11.3 |
| missing | 284 | 13 | 10 | 40 | ||||
| TP53(rs1042522)* | ||||||||
| GG (Arg/Arg) | 651 | 53.4 | 424 | 54.2 | 807 | 53.6 | 759 | 53.2 |
| GC (Arg/Pro) | 468 | 38.4 | 297 | 37.9 | 591 | 39.2 | 558 | 39.1 |
| CC (Pro/Pro) | 101 | 8.3 | 62 | 7.9 | 109 | 7.2 | 109 | 7.6 |
| missing | 222 | 11 | 749 | 114 | ||||
*
n=2256 in HEBCS