Table 2.
Breast surgical procedure and clinical and pathologic response to neoadjuvant chemotherapy by tumor subtype
| Characteristic | All Patients (n = 694) | Triple- Negative (n = 170) | HER2-Positive (n = 207) | Hormone- Receptor- Positive, HER2- Negative (n = 317) | P Value |
|---|---|---|---|---|---|
| Clinical tumor size after chemotherapy, median (range), cm | 1.4 (0-15.8) | 1.2 (0-11.0) | 1.2 (0-12.5) | 1.5 (0-15.8) | 0.10 |
| Clinical response | 0.48 | ||||
| Complete response | 166 (27.4) | 36 (24.0) | 58 (33.3) | 72 (25.4) | |
| Partial response | 324 (53.4) | 83 (55.3) | 89 (51.2) | 152 (53.7) | |
| Stable disease | 79 (13.0) | 20 (13.3) | 19 (10.9) | 40 (14.1) | |
| Disease progression | 38 (6.3) | 11 (7.3) | 8 (4.6) | 19 (6.7) | |
| Unknown | 87 | 20 | 33 | 34 | |
| Pathologic response, breast tumor | <0.0001 | ||||
| Complete response | 233 (33.8) | 81 (47.9) | 103 (50.2) | 49 (15.5) | |
| Partial response | 318 (46.1) | 60 (35.5) | 80 (39.0) | 178 (56.3) | |
| Stable disease | 96 (13.9) | 22 (13.0) | 15 (7.3) | 59 (18.7) | |
| Disease progression | 43 (6.2) | 6 (3.6) | 7 (3.4) | 30 (9.5) | |
| Unknown | 4 | 1 | 2 | 1 | |
| Pathologic tumor size in cases with residual disease, median (range), cm | 1.8 (0.1-22.5) | 1.8 (0.1-9.0) | 1.7 (0.1-9.0) | 2.0 (0.1-22.5) | 0.026 |
| Pathologic N category | <0.0001 | ||||
| N0 | 285 (41.1) | 84 (49.4) | 134 (64.7) | 67 (21.1) | |
| N1 | 241 (34.7) | 55 (32.4) | 53 (25.6) | 133 (43.0) | |
| N2 | 129 (18.6) | 26 (15.3) | 16 (7.7) | 87 (27.4) | |
| N3 | 39 (5.6) | 5 (2.9) | 4 (1.9) | 30 (9.5) | |
| Unknown | 0 | 0 | 0 | 0 | |
| Largest lymph node metastasis in cases with residual positive nodes, median (range), cm | 0.9 (0.01-8.0) | 1.0 (0.01-4.5) | 0.7 (0.04-4.0) | 0.9 (0.01-8.0) | 0.056 |
| Number of breast operations | 0.039 | ||||
| 1 | 643 (92.7) | 164 (96.5) | 193 (93.2) | 286 (90.2) | |
| 2 or more | 51 (7.3) | 6 (3.5) | 14 (6.8) | 31 (9.8) | |
| Final breast surgery | 0.019 | ||||
| Breast-conserving surgery | 277 (40.0) | 79 (46.8) | 89 (43.0) | 109 (34.5) | |
| Mastectomy | 415 (60.0) | 90 (53.2) | 118 (57.0) | 207 (65.5) | |
| pCR (breast and axilla) | 195 (28.1) | 65 (38.2) | 94 (45.4) | 36 (11.4) | <0.0001 |
| pCR in breast only | 233 (33.6) | 81 (47.6) | 103 (49.8) | 49 (15.5) | <0.0001 |
| pCR in axilla only | 285 (41.1) | 84 (49.4) | 134 (64.7) | 67 (21.1) | <0.0001 |