Table 3.

Mutations observed in the phosphorylation site motifs of p53 (Bold fonts are for motifs not following consensus sequence).

pS/pT	P−3	P−2	P−1	P0	P +1	P +2	P +3	Total	Amino Acid Pair
N- and C-Terminus Domains
S6	0	3	1	2	1	2	0	9	D/S, Q/S
S9	2	1	2	0	1	11	2	19	P/S, V/S
S15	2	1	0	1	1	1	0	6	L/S, Q/S
T18	1	1	1	0	0	0	0	3	E/T, F/T
S20	1	0	0	0	0	0	0	1	D/S, F/S
S33	1	2	0	1	1	3	1	9	P/S, L/S
S37	1	3	1	2	0	2	0	9	P/S, Q/S
S46	1	4	1	5	8	1	8	28	P/S, L/S
T55	1	4	2	0	5	0	2	14	E/T, F/T
T81	3	4	2	2	9	3	10	33	P/T, P/T
S99	6	3	6	4	1	4	7	31	P/S, Q/S
S106	0	3	11	8	5	3	6	36	S/G, S/Y
S313	4	6	8	4	1	3	2	28	T/S, S/S
S314	6	8	4	1	3	2	9	33	S/S, S/S
S315	8	4	1	3	2	9	3	30	P/S, S/S
S362	0	1	0	0	1	3	2	7	S/G, R/S
S366	2	3	2	2	0	0	0	9	S/S, H/S
S376	0	0	0	2	0	0	2	4	Q/S, T/S
T377	0	0	2	0	0	2	0	4	S/S, S/S
S378	0	2	0	0	2	0	0	4	T/S, R/S
T387	0	1	0	0	0	1	0	2	E/T, T/K
S392	1	0	0	1	0			2	D/S, D/S
Sum (N- and C-terminus)	41	54	44	38	41	50	54
Core Domain
S149	14	32	16	16	14	190	141	423	D/S, T/S
T150	32	16	16	14	190	141	36	445	T/S, P/T
T155	141	36	85	79	85	228	247	901	S/G, R/S
S183	18	88	13	6	39	16	15	195	S/D, S/C
T211	39	15	14	30	16	81	87	282	T/N, F/T
S215	16	81	87	86	94	16	45	425	S/H, S/V
S269	187	57	17	20	102	54	169	606	N/S, F/S
Sum (core domain)	447	325	248	251	540	726	740

Based on IARC p53 mutation database Release R16, which contains 29573 somatic mutations in sporadic cancers reported [85].