Table 4.
Prediction of Gleason sum ≥7 at prostatectomy.
| Predictors | Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|
| Base Model | Base Model + PHI | ||||
| OR (95% CI) |
p Value | AUC ((95% CI) |
OR ((95% CI) |
OR ((95% CI) |
|
| Age | 1.067 (0.989–1.153) |
0.099 | 62.5% (50.1–74.8) |
1.018 (0.935–1.110) |
1.047 (0.954–1.150) |
| DRE findings | 1.705 (0.471–6.177) |
0.393 | 53.8% (45.7–61.9) |
0.959 (0.215–4.275) |
1.413 (0.268–7.438) |
| Serum total PSA | 1.022 (0.926–1.127) |
0.658 | 52.2% (38.0–66.4) |
0.966 (0.856–1.091) |
0.867 (0.738–1.018) |
| Biopsy Gleason sum | 20.698 (4.626–92.615) |
<0.0001 | 79.2% (71.8–86.5) |
21.505 (4.418–104.677) |
18.839 (4.018–88.335) |
| PHI | 1.030 (0.998–1.062) |
0.028 | 66.6% (54.4–78.7) |
- | 1.049 (1.002–1.097) |
| AUC (multivariate models) | 81.3% (71.1–91.5) |
86.1% (79.0–93.1) |
|||
| Gain in predictive accuracy * | - | +4.8 | |||
| p value * | - | NS | |||
All variables were treated as continuous variables except DRE (digital rectal examination; suspicious vs. non suspicious) and Gleason sum at biopsy (6 vs. ≥7). *: as compared with the base model. AUC: area under receiver operating curves; NS: not significant; OR: odds ratio; PHI: Prostate Health Index; PSA: prostate-specific antigen.