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Effect of PD98059 on the production of PIP and OCN induced by SP. After the MSCs reached confluence, the culture medium was replaced with osteogenic medium containing SP (0 or 10 ng/mL), or SP (10 ng/mL) with the ERK 1/2 inhibitor, PD98059 (10 µM) and the cells were cultured for 7 (A) or 14 (B) days. * p < 0.05, SP (0 ng/mL) vs. SP (10 ng/mL), † p < 0.05, SP (10 ng/mL) vs. SP (10 ng/mL) with PD98059 (10 µM).
