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. 2014 Aug 15;15(8):14298–14312. doi: 10.3390/ijms150814298

Figure 6.

Figure 6

miR-16 is involved in ART regulation of COX-2 expression in bladder cancer cells. The level of miR-16 was detected in T24 and RT4 cells transfected with miR-16 mimic for 24 h. * p < 0.05, compared to negative control (A); COX-2 protein expression (B) in T24 and RT4 cells and PGE2 levels (C) in the supernatants of T24 and RT4 cells transfected with miR-16 mimic for 24 h. * p < 0.05, compared to negative control; After transfection with miR-16 inhibitor for 24 h, T24 and RT4 cells were added with ART for an additional 24 h, and then COX-2 mRNA and protein level was measured (D,E); After transfected with miR-16 inhibitor for 24 h, T24 and RT4 cells were added with ART for an additional 24 h, and then PGE2 levels in the supernatants were determined (F). * p < 0.05, compared to vehicle controls group. # p < 0.05, compared to negative control. $ p < 0.05, compared to negative control +ART (100 μM) treated group.