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. 2014 Aug 18;15(8):14313–14331. doi: 10.3390/ijms150814313

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Signal integration between interferon gamma (IFNγ) and Toll-like receptors (TLRs) involves interactions of STAT1, interferon-regulated factor (IRF)1, IRF8 and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB). Analysis of gene expression profiles of atherosclerotic plaques together with the results of microarray experiments conducted by our group on STAT1 -/- SMC [Chmielewski S. et al.] create this complex signal integration picture (see Discussion). STAT1 regulates genes by itself, but also interacting with IRF1, IRF8 or NFκB.