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. 2014 Aug 18;15(8):14396–14410. doi: 10.3390/ijms150814396

Figure 5.

Figure 5

Immunohistochemistry assays of5-bromo-2'-deoxyuridine (BrdU)-positive neurons in thesubventricular zone (SVZ) and subgranular zone (SGZ).Brown immunoreactive cells imply the BrdU-positive neurons in mice brain (see arrows, bars = 100 μm). Compared with controls, significantlymore BrdU-positive cells were observed in the SVZ (a) and SGZ (c) of AD-like mice and AD+SFN-like mice. Moreover, sulforaphane significantly increased the numbers of BrdU-positive cells in the SVZ (a) and SGZ (c) of AD-like mice;(b) and (d) showed quantitative assessments of BrdU-positive cells in SVZ and SGZ, respectively. (n = 8; means ± S.E.M.; One-way analysis of variance followed by post hoc least significant difference multiple comparison tests; * p < 0.05 versus control, # p < 0.05 versus AD; ** p < 0.05 versus control; magnify 200×; numbers of BrdU-positive neurons of each field of vision in both SVZ and SGZ were counted).