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. 2014 Aug 19;15(8):14411–14426. doi: 10.3390/ijms150814411

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Hierarchical cluster analysis using total miRNA of PBMC in IA and IT stages of Chronic HBV infection. (A) IT of CHB vs. IA of CHB; (B) IT of CHB vs. NC; (C) IA of CHB vs. NC. Legend: IT, immune tolerance; IA, immuneactivation; NC, normal control; CHB, chronic hepatitis B. Note: (1) Red represents that the upregulation of miRNA; Green represents a downregulation of miRNA; (2) The PBMCs of three subjects fromthe samegroup were pooled and four or three pools were analyzed in the microarray groups.