Table 1.
Biosynthetic Pathway | Modification Enzymes | Putative Function | CDP Substrate |
---|---|---|---|
Thaxtomin [24,69,70] (Streptomyces scabies) |
TxtC | Hydroxylation | cWY |
Brevianamide [71] (Aspergillus fumigatus) |
Afu8g00240 | Oxidative cyclization | cWP |
Afu8g00230 | Oxidative cyclization | ||
Afu8g00220 | Hydroxylation | ||
Afu8g00200 | O-methylation | ||
Afu8g00190 | Hydroxylation | ||
Ergotamine [72] (Claviceps purpurae) |
CpP4501 | Hydroxylation | cFP |
CpCAT2 | Hydroperoxidation | ||
CpOX3 | Oxidative cyclization | ||
Meleagrin [73] (Penicillium chrysogenum) |
Pc21g15430 | C3-reverse-prenylation | cWH |
Pc21g15440 | O-methylation | ||
Pc21g15450 | Oxidative cyclization | ||
Pc21g15460 | N-hydroxylation | ||
Pc21g15470 | α,β-dehydrogenatioin | ||
Acetylazonalenin [74] (Neosartorya fischeri) |
AnaPT | C3-reverse-prenylation | cWF |
AnaAT | N-acetylation | ||
Gliotoxin [75] (Aspergillus fumigatus) |
GliC | Oxidation | cFS |
GliF | Oxidation | ||
GliG | Sulfurization | ||
GliI | Cyclopropane-formation | ||
GliM | O-methylation | ||
GliN | N-methylation |