. 2014 Aug 22;15(8):14786–14802. doi: 10.3390/ijms150814786

Table 4.

Distribution of genotypes and alleles of the c.–441G>A (rs174538) and the g.61564299G>T (rs4246215) polymorphisms of the FEN1 gene and the odds ratio (OR) with the 95% confidence interval (95% CI) in patients with keratoconus (KC) and controls.

Polymorphism Genotype/Allele	Controls (n = 322)		KC (n = 279)		Crude OR (95% CI)	p	Adjusted OR ^a (95% CI)	p
Polymorphism Genotype/Allele	Number	Frequency	Number	Frequency	Crude OR (95% CI)	p	Adjusted OR ^a (95% CI)	p
c.-441G>A
A/A	17	0.05	17	0.06	1.16 (0.58–2.33)	0.667	1.28 (0.38–4.25)	0.689
A/G	178	0.55	161	0.58	1.10 (0.80–1.52)	0.550	0.64 (0.40–1.05)	0.079
G/G	127	0.39	101	0.36	0.87 (0.63–1.21)	0.414	1.52 (0.92–2.51)	0.104
χ² = 0.745; p = 0.6891
A	212	0.33	195	0.35	1.13 (0.85–1.49)	0.390	0.75 (0.49–1.16)	0.200
G	432	0.67	363	0.65	0.88 (0.67–1.17)	0.390	1.33 (0.86–2.06)	0.200
g.61564299G>T
G/G	149	0.46	106	0.38	0.71 (0.51–0.99)	0.042	0.96 (0.59–1.55)	0.860
G/T	157	0.49	141	0.51	1.07 (0.78–1.48)	0.663	0.74 (0.46–1.20)	0.219
T/T	16	0.05	32	0.11	2.48 (1.33–4.62)	0.004	5.15 (1.69–15.67)	0.004
χ² = 10.420; p = 0.0055
G	455	0.71	353	0.63	0.68 (0.52–0.88)	0.004	0.76 (0.51–1.14)	0.185
T	189	0.29	205	0.37	1.47 (1.13–1.91)	0.004	1.31 (0.88–1.96)	0.185

p < 0.05 along with corresponding ORs are in bold; OR ^a adjusted for sex, age, co-occurrence of visual impairment, allergies, heart and vascular diseases and family history for KC.