Table 6.
Distribution of haplotypes of c.–441G>A (rs174538) and the g.61564299G>T (rs4246215) polymorphisms of the FEN1 gene and the odds ratio (OR) with the 95% confidence interval (95% CI) in patients with KC and FECD and controls.
| Haplotype | Controls (n = 322) | KC (n = 279) | OR (95% CI) | p | FECD (n = 225) | OR (95% CI) | p | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Frequency | Number | Frequency | Number | Frequency | |||||
| AG | 221 | 0.17 | 178 | 0.16 | 1.09 (0.88–1.35) | 0.427 | 110 | 0.12 | 1.49 (1.16–1.90) | 0.002 |
| AT | 203 | 0.16 | 212 | 0.19 | 0.79 (0.65–0.99) | 0.036 | 140 | 0.16 | 1.02 (0.80–1.28) | 0.897 |
| GG | 689 | 0.53 | 528 | 0.47 | 1.28 (1.10–1.50) | 0.002 | 510 | 0.57 | 0.88 (0.74–1.04) | 0.142 |
| GT | 175 | 0.14 | 198 | 0.18 | 0.73 (0.58–0.91) | 0.051 | 140 | 0.16 | 0.85 (0.67–1.09) | 0.197 |
p < 0.05 along with corresponding ORs are in bold.