Table 2.
Densitometric analysis of western blot results.
| Parameters | Sham ( n = 10) | MI ( n = 10) | MI-Simvastatin ( n = 10) |
|---|---|---|---|
| Fibrosis (%) | 0.24 ± 0.09 ( n = 7) | 2.30 ± 0.71 * ( n = 7) | 1.17 ± 0.16 # ( n = 7) |
| eNOS | 13.41 ± 2.58 ( n = 6) | 6.75 ± 2.05 * ( n = 6) | 12.06 ± 3.43 # ( n = 6) |
| iNOS | 0.28 ± 0.30 ( n = 9) | 7.33 ± 5.79 * ( n = 10) | 1.60 ± 1.47 **,# ( n = 12) |
| I NCX | 0.79 ± 0.48 ( n = 8) | 14.52 ± 11.87 * ( n = 11) | 4.19 ± 11.87 *,## ( n = 12) |
| SERCA | 30.90 ± 3.18 ( n = 6) | 21.13 ± 1.36 * ( n = 6) | 25.43 ± 3.27 **,## ( n = 6) |
| TM | 2.54 ± 0.47 ( n = 6) | 0.80 ± 0.28 * ( n = 6) | 1.85 ± 0.38 # ( n = 6) |
| TFPI | 6.37 ± 0.71 ( n = 6) | 3.15 ± 0.22 ( n = 6) | 4.32 ± 0.47 ( n = 6) |
| tPA | 2.73 ± 0.12 ( n = 6) | 1.25 ± 0.12 ( n = 6) | 2.01 ± 0.13 ( n = 6) |
| Rac 1 | 16,165 ± 1696 ( n = 6) | 28,440 ± 1655 * ( n = 6) | 19,275 ± 2236 # ( n = 5) |
* p < 0.01 vs. sham, ** p < 0.05 vs. sham; # p < 0.001 vs MI + simvastatin; ## p < 0.01 vs. MI + simvastatin; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; NCX, sodium calcium exchanger; SERCA, sarcoplasmic reticulum Ca2+-ATPase; TM, thrombomodulin; TFPI, tissue factor pathway inhibitor; tPA, tissue plasminogen activator; Rac 1, Rac 1 GTPase; values in the table are GAPDH-normalized, except Rac1 GTPase.