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pO2 pressure data represented in histograph form. (A) The percent frequency of pO2 pressures as measured in an individual head and neck cancer patient. Reprinted by permission from Lartigau et al. (158); (B) HP2.5 distribution in the population. The hypoxic threshold is upper limit of the hypoxic range below which cellular, tissue, or organ function becomes progressively restricted (122). Reprinted by permission from Terris (262). HP2.5, hypoxic fraction below 2.5 mmHg.
