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From left to right: transaxial 18F-FDG PET; transaxial 18F-FMISO PET of head and neck tumors. (A) normoxic (HP2.5=13.0%; 18F-FDGSUVmean=14.80; 18F-FMISOT/M=1.31). (B) hypoxic (HP2.5=37.7%; 18F-FDGSUVmean=8.00; 18F-FMISOT/M=1.60). Reprinted by permission from Gagel et al. (95). 18F-FDG, 18F-fluorodeoxyglucose; HP2.5, hypoxic fraction below 2.5 mmHg; SUV, standard uptake value; T/M, tumor to muscle ratio.
