Table 2.

miRNAs differentially expressed in histological subtypes of lung cancer

miRNA	Expression in subtype			Confirmed targets	References
	SqCC	AdC	SCLC
let-7	Dn			HMGA2, RAS, MYC, E2Fs, CDKs	[24, 25, 54, 65, 77, 78, 80, 81, 105]
miR-9			Up	TGFBI, TRIM2, SIRT1, BTBD3	[24, 25, 54, 106]
miR-17-92 cluster			Up	p21, E2F, CCND1, PTEN, Rb, HIF-1α	[40, 54]
miR-31		Up		LATS2, PPP2R2A	[10, 23, 46, 64, 65]
miR-93			Up	p21, FUS1	[10, 54, 111, 118]
miR-95			Up	SNX1	[25, 54, 119]
miR-98			Up	FUS1	[10, 54, 93, 118]
miR-128			Up	EGFR	[45, 54]
miR-130b	Up			CSF-1, TP53INP1, RUNX3	[54, 64, 65]
miR-139	Dn			ROCK2, FOXO1, CXCR4	[24, 64, 65, 123–125]
miR-140		Dn		Sp1, BMP2	[25, 64]
miR-143		Dn		ERK5, KRAS, Bcl-2, DNMT3A, ELK1	[23–25, 54, 64]
miR-146b		Up		MMP16, TRAF6, IRAK1,	[25, 54, 77, 78, 107]
miR-149	Up			E-cadherin	[10, 55, 65]
miR-150		Dn		MUC4, P2RX7	[25, 54, 64]
miR-155		Up		TAB2, FADD, RIP-1, IKKε, ET-1	[25, 54, 61, 77, 78, 107]
miR-182		Up		FOXO1	[24, 54, 61, 64, 65, 77, 78, 80, 95, 120]
miR-191		Up		CDK6, TIMP3, NDST1	[25, 54, 77, 78, 107]
miR-192		Up		ERCC3, ERCC4, Rb1	[25, 107]
miR-200a,b		Up		C-ets-1, Zeb1, ECM proteins, p38α	[54, 64, 79, 127]
miR-200c	Up			C-ets-1, Zeb1, ECM proteins	[54, 65, 77, 128]
miR-203		Up		DeltaNp63, Smo	[25, 77, 107]
miR-205	Up			E2F1, Zeb1, Sip1	[10, 25, 65, 74, 75, 78, 93, 107]
miR-218		Dn		RICTOR	[24, 25, 64]
miR-324-5p	Up			Smo, Gli1	[10, 54, 65, 130]
miR-375			Up	IGF1R, SP1, LDHB, YAP1	[54, 64, 137–140]
miR-423	Up			p21	[24, 65, 141]
miR-429	Dn			ALDH1L2, PSAT1, ZEB1	[54, 65, 142]
miR-486		Dn		CD40	[64, 65, 108]

Note: Targets cited are confirmed by experiments