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Effects of PKA activity on ethanol-induced loss of righting reflex. aCSF (Veh), PKA activator Sp-cAMP (Sp), or PKA inhibitor Rp-cAMP (Rp) was administered intracerebroventricularly 15 minutes prior to a 4.0 g/kg ethanol dose in (A) adolescents (P35) and (B) adults (P75). Data are presented as mean ± SEM. *p < 0.05 compared to age-matched vehicle controls; n = 8–12 per group.
