TABLE 5.

Clinicopathologic Characteristics in Relation to EGFR Mutation Status in Studies Containing Primarily Asian Patients^a

	EGFR Mutation Prevalence, %	EGFR Mutation Positive	EGFR Mutation Negative	n (N)
Age with cutoff, y
<65b	46	370	433	6 (803)
≥65c	38	432	709	5 (1141)
Sex
Femaled	58	1027	733	27 (1760)
Malee	32	456	962	26 (1418)
Smoking
Neverf	58	843	599	22 (1442)
Everf	26	265	767	22 (1032)
History of smoking, pack-years
0–10g	67	10	5	1 (15)
11–40g	45	5	6	1 (11)
>40g	23	5	17	1 (22)
>20h	25	13	40	1 (53)
Histology
Adenocarcinomai	50	1278	1256	25 (2534)
Squamousj	5	8	160	8 (168)
Adenosquamousk	67	4	2	2 (6)
Large celll	7	1	14	4 (15)
Differentiation
Two grades
Wellm	37	62	107	3 (169)
Moderate to poorm	14	27	162	3 (189)
Three grades
Welln	65	28	15	2 (43)
Moderaten	48	59	63	2 (122)
Poorn	34	17	33	2 (50)

Abbreviations: n, number of studies; N, number of patients.

^aMost studies contained primarily patients with adenocarcinoma.

^bReferences ^{7, 55, 184, 272, 276, 290}.

^cReferences ^{55, 184, 272, 276, 290}.

^dReferences ^{7, 32, 35, 48, 49, 55, 133, 184, 185, 257, 264, 269, 270, 272, 274–276, 278, 283–287, 289–291, 296}.

^eReferences ^{32, 35, 48, 49, 55, 133, 184, 185, 257, 264, 269, 270, 272, 274–276, 278, 283–287, 289–291, 296}.

^fReferences ^{32, 35, 55, 133, 184, 185, 257, 264, 269, 270, 274–276, 278, 283–285, 287, 289–291, 296}.

^gReference ²⁹⁰.

^hReference ²⁷².

ⁱReferences ^{32, 35, 48, 49, 55, 133, 184, 185, 257, 264, 269, 270, 272, 274–276, 278, 283–286, 289–291, 296}.

^jReferences ^{55, 257, 264, 272, 274, 275, 289, 296}.

^kReferences^{272, 289}.

^lReferences^{48, 272, 275, 289}.

^mReferences ^{119, 184, 202}.

ⁿReferences ^{49, 184}.