TABLE 6.

Clinicopathologic Characteristics in Relation to EGFR Mutation Status in Studies Containing Primarily Non-Asian Patients^a

	EGFR Mutation Prevalence, %	EGFR Mutation Positive	EGFR Mutation Negative	n (N)
Sex
Femaleb	28	859	2239	19 (3098)
Maleb	18	397	1768	19 (2165)
Smoking
Neverc	45	666	805	18 (1471)
Everc	15	569	3154	18 (3723)
History of smoking, pack-years
0–10d	39	18	28	1 (46)
11–50d	8	7	86	1 (93)
>50d	5	3	56	1 (59)
Histology
Adenocarcinomae	24	1266	3918	19 (5184)
Squamousf	5	6	104	9 (110)
Adenosquamousg	13	1	7	2 (8)
Large cellh	5	2	37	6 (39)

Abbreviations: n, number of studies; N, number of patients.

^aMost studies contained primarily patients with adenocarcinoma.

^bReferences ^{17, 32, 87, 115, 128, 191–193, 253, 254, 256, 267, 273, 288, 292–295, 297}.

^cReferences ^{17, 32, 87, 128, 191–193, 253, 254, 256, 267, 273, 288, 292–295, 297}.

^dReference ²⁸⁸.

^eReferences ^{17, 32, 87, 115, 128, 191–193, 253, 254, 256, 267, 273, 288, 292–294, 297, 298}.

^fReferences ^{17, 191, 193, 254, 256, 267, 273, 288, 298}.

^gReferences ^{17, 288}.

^hReferences^{17, 193, 254, 267, 273, 298}.