TABLE 7.
Clinicopathologic Characteristics in Relation to ALK Rearrangement Statusa
| ALK Rearrangement Prevalence, % | ALK Rearrangement Positive | ALK Rearrangement Negative | n (N) | |
|---|---|---|---|---|
| Age with cutoff, y | ||||
| ≤6520 | 6 | 13 | 210 | 1 (223) |
| >6520 | 3 | 6 | 224 | 1 (230) |
| Sex | ||||
| Females11,12,15,20 | 5 | 28 | 579 | 4 (607) |
| Males11,12,15,20 | 4 | 30 | 738 | 4 (768) |
| Smoking | ||||
| Never11,15,20 | 8 | 30 | 331 | 3 (361) |
| Ever11,15,20 | 3 | 20 | 652 | 3 (672) |
| Ethnicity | ||||
| Asian/Pacific11,12,14 | 5 | 35 | 654 | 3 (689) |
| White (Caucasian)12,15 | 4 | 22 | 474 | 2 (496) |
| Histology | ||||
| Adenocarcinoma9,11,12,15,16,19,20 | 5 | 67 | 1319 | 7 (1386) |
| Squamous9,11,12,16,19,20 | 0.2 | 1 | 522 | 6 (523) |
| Adenosquamous11,12,19 | 0 | 0 | 19 | 3 (19) |
| Differentiation | ||||
| Well11 | 1 | 1 | 97 | 1 (98) |
| Not well11 | 6 | 10 | 145 | 1 (155) |
Abbreviations: n, number of studies; N, number of patients.
a
Most studies contained primarily patients with adenocarcinoma.