FIGURE 1.

Long-term therapy (1 year after injection at 6 months of age) with shCDK5miR in 3xTg-AD mice prevented the spatial memory deficit. Therapy with shCDK5miR had a beneficial effect on spatial memory by MWM testing. (A) Values of latency to reach the hidden platform during training show significant difference in the learning and probe trial tests at 48 h. This effect was replicated in (B) time spent in the target quadrant and (C) path plots for the median path length. (TQ = target quadrant, RQ = Right quadrant, UQ = upper quadrant and OQ = oppositive quadrant.) Data are presented as mean ± SEM. n = 18 by each group, *p < 0.05, **p < 0.01.