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. 2013 Jul 25;280(18):4407–4416. doi: 10.1111/febs.12422

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© 2013 The Authors. FEBS Journal published by John Wiley & Sons Ltd on behalf of FEBS

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Heterogeneity of CFTR R region:NBD1 interactions. N‐terminus of the R region (red, residues 638–671) in different NBD1 crystal structures (A, 1R0X; B, 1XMI) oriented to show the NBD dimerization interface 15. The core NBD1 (surface representation) is colored as a gold gradient reflecting the proximity to atoms in the other NBD1 molecule within the NBD1:NBD1 homodimer structure (2PZE). The flexible regulatory insertion (RI) of NBD1 that is in different conformations in the two structures is shown as gray helices and is not part of the surface representation.